Bio

Dr. Magness’ research is focused on the basic biology of intestinal stem cells, the genes that control their behavior, and translational approaches to stem cell-based therapies for human disease and injury of the intestine. Furthermore, his research focuses on elucidating genetic mechanisms underlying stemness and developing translational models to establish a finer understanding of stem cell-driven regeneration dynamics in homeostasis and injury. Using a combination of genetic mouse models and micro-fabricated bioengineered platforms, Dr. Magness’ team is exploiting the self-renewal capacity and multi-potency of ISCs to develop long-term ex vivo models of the intestine and colon with primary tissues. These biomimetic models offer new solutions for compound screening and cell-based therapies.

Research Interests

Stem Cell Biology
Niche Dynamics
Tissue Engineering
Biomimetic Scaffolds
Single-Cell Biology
Stem cell maintenance and differentiation
Single cell analytics
High-throughput biomimetic culture platforms

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