Primary Research Area:

Biomedical Engineering including Biofluids Modeling, Biomechanics, Mathematical Modeling, Physiological Systems, Vascular Hemodynamics

Intelligent Systems and Bioengineering including Automatic Control / Adaptive Control, Biomedical Systems, Large-Scale Non-linear Systems / Distribution Systems

Research Interests:

Cardiovascular Physiology, Biofluid Dynamics, Mathematical Modeling, Mathematical biology.

Education:

M.S. in Computer Science, Roskilde University, Roskilde, Denmark
M.S. in Mathematics, Roskilde University, Roskilde, Denmark
Ph.D. in Applied Mathematics, Roskilde University, Roskilde, Denmark

About Dr. Mette Sofie Olufsen:

Professor Mette Olufsen received a M.S. in mathematics and computer science (1993) and a Ph.D. (1998) all from Roskilde University, Denmark. While pursuing her doctorate degree, she worked for Math-Tech, Copenhagen, as a research scientist on a project that aimed at developing an anesthesia simulator. Later she had a postdoc at the Center for BioDynamics and Department of Mathematics, Boston University. She joined the Mathematics Department at NCSU in the fall of 2001.

Mette Olufsen is a mathematical biologist specializing in modeling of physiological systems. Her main interest is in modeling fluid dynamics of arterial blood flow and understanding cardiovascular blood pressure and blood flow control. Specifically understanding the dynamics involved with standing up too quickly, running, or head up tilt.

Recent Publications:

1. M.S. Olufsen and J. Ottesen. Outflow conditions in human arterial flow. In Computer simulations in biomedicine, Proc Third Int Conf Comput Simul Biomed, Biomed '95. H. Power, R.T. Hart (eds). Computational Mechanics Publications, 249-256, 1995
2. M.S Olufsen. A structured tree outflow condition for blood flow in the large systemic arteries, Am J Physiol, 276:257-268, 1999
3. M.S. Olufsen, A. Nadim, L. Lipsitz. Autoregulation of cerebral blood flow. Proc IEEE 26th Ann Northeast Bioeng Conf, 41-42, 2000
4. M.S. Olufsen, C.S. Peskin, W.Y. Kim, E.M. Pedersen, A. Nadim, J. Larsen. Numerical simulation and experimental validation of blood flow in arteries with structured-tree outflow conditions. Ann Biomed Eng, 28(11):1281-1299, 2000
5. M.S. Olufsen, L.A. Lipsitz, and A. Nadim. A Lumped Parameter Model for Cerebral Blood Flow Regulation. Advances in Bioengineering, 51:277-278, 2001
6. M.S. Olufsen. A one-dimensional fluid dynamic model of the systemic arteries. In Computational Modeling in Biological Fluid Dynamics, L.J. Fauchi and S. Gueron (eds), IMA Volumes in Mathematics and its Applications, 124:167-188, 2001
7. M.S. Olufsen, A. Nadim, and L.A. Lipsitz. Dynamics of cerebral blood flow regulation explained using a lumped parameter model. Am J Physiol, Reg Int Comp Physiol, 282:611-622, 2002
8. M.S. Olufsen, A. Nadim. Lumped models for blood flow and pressure in the systemic arteries. Proc 2nd MIT conf Comp Fluid and Solid Mech, K.J. Bathe (ed). Elsevier Science, 2:1786-1789, 2003
9. M.S. Olufsen, M.A. Whittington, M. Camperi, N. Kopell. New roles for the gamma rhythm: Population tuning and preprocessing, J Comp Neurosci, 13:33-54, 2003
10. M.S. Olufsen, A. Nadim. On deriving lumped models for blood flow and pressure in the systemic arteries, Math Biosci Eng, 1(1): 61-80, 2004
11. M.S. Olufsen, H.T. Tran, L.A. Lipsitz. Modeling Cerebral Blood Flow Control During Posture Change fro Sitting to Standing, J Cardiovasc Eng, 4(1): 47-58, 2004
12. D.H. Justice, H.J Trussell, M.S. Olufsen. Modeling of blood flow velocity and pressure signals using the multipulse method. Proc 11th IEEE Digital Signal Processing Workshop, 320-324, 2004
13. J.T. Ottesen, M.S. Olufsen, J.K Larsen. Mathematical Models in Human Physiology. SIAM, 2004
14. B.N. Steele, M.S. Olufsen, C.A. Taylor. Impedance boundary condition for rest and exercise with in vivo validation, Submitted, Nov 2004
15. M.S. Olufsen, J.T. Ottesen, H.T. Tran, L.M. Ellwein, L.A. Lipsitz, V. Novak. Blood Pressure and blood flow variation during postural change from sitting to standing -Mathematical modeling and experimental validation, Submitted, Jan 2005

Date of Last Modification: 5/17/2009

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