Primary Research Area:

Biomedical Engineering including Functional Tissue Engineering, Microscopy, Tissue Mechanics, Veterinary Medicine

Research Interests:

Investigative dermatology and toxicology. Nanomaterial interactions with biological systems.

Education:

PhD: 1981 Purdue University, Veterinary Anatomy and Cell Biology
Postdoctoral Fellow: 1982-1984: Chemical Industry Institute of Toxicology, Research Triangle Park, NC.

About Dr. Nancy A. Monteiro-Riviere:

Dr Nancy Monteiro-Riviere is involved with creating new scaffolds with
bioenginered nanofibers for cell growth. She is interested in the nature of
fullerene nanomaterial interaction with biological systems.
Her primary research focus is the study of chemical interactions with the
skin. This has involved integrating compound exposure with absorption to
assess how chemical interactions with keratinocytes modify toxicity to the
skin as well as further chemical absorption. I have been particularly
interested in assessing the mechanism behind how multiple chemical exposures
modulates interaction of a single chemical with keratinocytes. Skin function
is assessed by studying proinflammatory cytokines using RT-PCR and changes
in keratinocyte proteins using proteomics. An important interaction that is
unique to chemical exposure to skin is the interaction that occurs with the
lipids in the stratum corneum barrier. These have been explored using
Fourier Transform InfraRed (FTIR) imaging as well as electron microscopy.
Model systems employed include human epidermal keratinocyte cell cultures as
well as a unique perfused skin model developed in our Center that has been
validated to be predictive of human absorption. I am fascinated by those
problems involving exposure to skin of chemicals that modulates their
subsequent absorption or activity either through changes induced in the
stratum corneum lipid barrier or keratinocyte proteome. We have studied the
mechanism of skin toxicity when model drugs are delivered by iontophoresis
or electroporation, investigating how physical changes in membrane function
or absorption pathways induced by electrical currents modify chemical
interactions with membrane and cellular targets. We have recently applied
these techniques to investigating the interaction of double-walled carbon
nanotubules with human keratinocytes.

CCTRPHomepage: http://cctrp.ncsu.edu

Recent Publications:

1. Monteiro-Riviere NA, Nemanich RJ, Inman AO, Wang YY, Riviere JE: Multi-walled carbon nanotube interactions with human epidermal keratinocytes. Toxicology Letters 155: 377-384, 2005. [ Related link ]
2. Xia XR, Baynes RE, Monteiro-Riviere NA, Riviere JE. Determination of the partition coefficient and absorption kinetic parameters of chemicals in a lipophilic membrane/water system by using a membrane coated fiber technique. European Journal of Pharmaceutical Sciences 24: 15-23, 2005 [ Related link ]
3. Udomkusonsri P, Noga EJ, Monteiro-Riviere NA: Pathogenesis of the acute ulceration response (AUR) in hybrid striped bass. Diseases of Aquatic Organisms 61: 199-213, 2004.
4. Muhammad F, Monteiro-Riviere NA, Riviere JE: Comparative in vivo of topical JP-8 jet fuel and its individual hydrocarbon components: Identification of tridecane and tetradecane as key constituents responsible for dermal irritation. Toxicologic Pathology 33: 258-266, 2005.
5. Muhammad F, Monteiro-Riviere NA, Baynes RE, Riviere JE. Effect of in vivo jet fuel exposure on subsequent in vitro dermal absorption of individual aromatic and aliphatic hydrocarbon fuel constituents. Journal of Toxicology and Environmental Health (In Press)
6. Xia XR, Baynes RE, Monteiro-Riviere NA, Riviere JE: Lipophilic membrane uptake kinetics of jet fuel aromatic hydrocarbons from aqueous solutions studied by a membrane coated fiber technique. Toxicology Mechanisms and Methods (In Press).
7. Monteiro-Riviere NA: The Integument. In Textbook of Veterinary Histology. (Ed. J Eurell). Williams & Wilkins, Media, Pa. Chapter 16. (In Press).
8. Riviere JE, Baynes RE, Monteiro-Riviere NA, Smith CE: Quantitating absorption of complex chemical mixtures. Final Report, CDC OH 007555, pp.1-27, 2004.
9. Lin JY, Lin FH, Burch JA, Selim MA, Monteiro-Riviere NA, Grichnik JM, Pinnell SR: α -Lipoic acid is ineffective as a topical antioxidant for photoprotection of skin. Journal of Investigative Dermatology 123: 996-998, 2004. [ Related link ]
10. Xia XR, Baynes RE, Monteiro-Riviere NA, Riviere JE: Characterization of polyacrylate membrane-coated fibers used in chemical absorption studies with programmed thermal treatment and FT-IR microscopy. Analytical Chemistry 76: 4245-4250, 2004. [ Related link ]
11. Xia XR, Baynes RE, Monteiro-Riviere NA, Riviere JE: A compartment model for the membrane-coated fiber (MCF) technique used for determining the absorption parameters of chemicals through lipophilic membranes. Pharmaceutical Research 21: 1345-1352, 2004. [ Related link ]
12. Monteiro-Riviere NA, Inman A, Riviere JE: Skin toxicity of jet fuels: ultrastructural studies and the effects of substance P. Toxicology and Applied Pharmacology 195: 339-347, 2004. [ Related link ]

Date of Last Modification: 9/20/2007

Return To The Directory      Modify Your Directory Entry