Primary Research Area:

Biomedical Engineering including Biofluids Modeling, Biomechanics, BioMEMS, Fluid Dynamics, Mathematical Modeling, Medical Instrumentation, Nanometer Systems, Physiological Systems, Vascular Hemodynamics

Research Interests:

THEORY: Biofluid Dynamics. Nanofluid Flow in Microchannels. Two-phase Flow. Mathematical Modeling. Computational Fluid-Structure Interaction (FSI) Simulations.
APPLICATION: Vascular Particle-Hemodynamics. Stented Aneurysms. Lung-Aerosol Dynamics. Nanotherapeutics. Software for Arterial Disease Risk Assessment and Surgical Management.
DESIGN: Smart Inhaler System. Nano-drug Delivery System. Stent-grafts for Aortic Aneurysms.

Education:

Ph.D., Vanderbilt

Recent Publications:

1. C. Kleinstreuer (1997), “Engineering Fluid Dynamics- An Interdisciplinary Systems Approach”, Cambridge University Press, New York, NY.
   
   C. Kleinstreuer (2003), “Two-Phase Flow: Theory and Applications”, Taylor & Francis, Inc., New York, NY.
   
   C. Kleinstreuer (2005), “Biofluid Dynamics: Principles and Selected Applications” CRC Press, Boca Raton, FL (in preparation).
   
   C. Kleinstreuer and Z. Zhang (2005), “Computational analyses of JP-8 Fuel Droplet and Vapor Deposition in a Human Upper Airway Model”, in Toxicity of Jet Propulsion Fuels and Performance Additives, G.D. Ritchie and M. L. Witten (eds.), Taylor & Francis, Inc., New York, NY (Submitted for Publication).
   
   C. Kleinstreuer and P. W. Longest (2003), “Particle-Hemodynamics Analyses of End-to Side Anastomoses: A Computational Comparison Study”, in Vascular Grafts- Experiment and Modeling, A. Tura (ed.), WIT Press, Ashurst, UK.
   
   C. Kleinstreuer, J. R. Buchanan, M. Lei, and G. A. Truskey (2001), “Computational Analysis of Particle Hemodynamics and Prediction of the Onset of Arterial Diseases,” In: Cardiovascular Techniques: Biomechanical System Vol. II, C. Leondes (ed.), CRC Press, Boca Raton, FL.
   
   C. Kleinstreuer, M. Lei, and J. P. Archie (2001), “Hemodynamics Simulations and Optimal Computer-Aided Design of Branching Blood Vessels,” In: Cardiovascular Techniques: Biomechanical System Vol. II, C. Leondes (ed.), CRC Press, Boca Raton, FL.
   
   C. Kleinstreuer and S. Hyun (2000), “Computer Simulation of Dilute Suspension Flows in Branching Blood Vessels”, in Medical Applications of Computer Modeling: Cardiovascular and Ocular Systems, T.B. Martonen (ed.), WIT Press, UK.
   
   C. Kleinstreuer, S. Hyun and J. P. Archie (2000), “Computer-Aided Design and Optimal Surgical Reconstruction of the Carotid Artery Bifurcation”, in Medical Application of Computer Modeling: Cardiovascular and Ocular Systems, T. B. Martonen (ed.), WIT Press, UK.
   
2. Z. Li and C. Kleinstreuer, (2005), "A new wall stress equation for aneurysm-rupture prediction", Annals of Biomedical Engineering, Vol. 33(2):209-213
   
   Z. Li and C. Kleinstreuer, (2005), :Blood flow and structure interactions in a stented abdominal aortic aneurysm model", Medical Engineering&Physics, Vol. 27:
3. P.W. Longest, C. Kleinstreuer and J.R. Buchanan, (2004), “Efficient computation of micro-particle dynamics including wall effects”, Computers and Fluids, Vol. 33: 577-601.
   
   J.R. Buchanan, C. Kleinstreuer, S. Hyun, and G.A. Truskey, (2003), “Hemodynamics simulation and identification of susceptible sites of atherosclerotic lesion formation in a model abdominal aorta”, Journal of Biomechanics, 36: 1185-96.
   
   P.W. Longest and C. Kleinstreuer, (2003), “Comparison of blood particle deposition models for non-parallel flow domains”, Journal of Biomechanics, Vol. 36:421-430.
   
4. C. Kleinstreuer and J. Koo, (2004), “Computational analysis of wall roughness effects for liquid flows in micro-conduits” ASME Journal of Fluids Engineering, Vol. 126: 1-13.
   
   J. Koo, and C. Kleinstreuer, (2004), “Viscous dissipation effects in microtubes and microchannels,” International Journal of Heat and Mass Transfer, 47: 3159-3169
   
   J. Koo and C. Kleinstreuer, (2003), “Liquid flow in microchannels: Experimental observations and computational analyses of microfluidics effects”, J. Micromech. Microeng., Vol. 13: 568-579.
5. Z. Zhang, C. Kleinstreuer, J.F. Donohue, and C.S. Kim, (2005), “Comparison of micro- and nano-size particle depositions in a human upper airway model”, Journal of Aerosol Science, Vol. 36(2): 211-233.
   
   P. W. Longest, and C. Kleinstreuer, (2004), “Interacting effects of uniform flow, plane shear, and near-wall proximity on the heat and mass transfer of respiratory aerosols”, International Journal of Heat and Mass Transfer, Vol. 47: 4745-4759
   
   Z. Zhang, C. Kleinstreuer, C.S. Kim and Y.S. Cheng, (2004), “Vaporizing micro-droplet inhalation, transport and deposition in a human upper airway model”, Aerosol Science and Technology, Vol. 38: 36-49.
   
   Z. Zhang, and C. Kleinstreuer, (2004), “Airflow Structures and Nano-Particle Deposition in a Human Upper Airway Model”, Journal of Computational Physics, Vol. 198, 178-210
   
   H. Shi, C. Kleinstreuer, Z. Zhang, and C. S. Kim, (2004), “Nano-particle transport and deposition in bifurcating tubes with different inlet conditions”, Physics of Fluids, Vol. 16, 2199-2213.
   
   Z. Zhang and C. Kleinstreuer, (2003), “Species heat and mass transfer in a human upper airway model”, International Journal of Heat and Mass Transfer, Vol. 46: 4755-68.
   
   Z. Zhang and C. Kleinstreuer, (2003), “Computational thermodynamics analysis of vaporizing fuel droplets in the human upper airways”, JSME International Journal, Vol. 46: 563-571.
   
   C. Kleinstreuer, and Z. Zhang, (2003), "Targeted Drug Aerosol Deposition Analysis for a Four-Generation Lung Airway Model with Hemispherical Tumors", Journal of Biomedical Engineering, Vol. 125: 197-206.
   
   C. Kleinstreuer, and Z. Zhang, (2003), "Laminar-to-Turbulent Fluid-Particle Flows in a Human Airway Model", Int. J. Multiphase Flow, Vol. 29: 271-289.
   
   Z. Zhang, and C. Kleinstreuer, (2003), "Low Reynolds Number Turbulent Flows in Locally Constricted Conduits: A Comparison Study", AIAA Journal, Vol 41: 831-840.
   
   

Date of Last Modification: 7/18/2006

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